STRALSV - Structure Alignment-based Sequence Variability

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The StralSV service is under reconstruction.


This service allows submission of the protein structure (target in PDB format) for STRALSV analysis. Target structure will be structurally compared with all proteins from the provided list of PDB chains. Target will be split into smaller Structure Context Fragments, and each fragment will be evaluated separately. Results from all identified structure similarity regions will be combined and observed amino acid variabilities will be reported.


Citing STRALSV:
Zemla A.T, Lang D.M, Kostova T, Andino R, Zhou C.L. "StralSV: assessment of sequence variability within similar 3D structures and application to polio RNA-dependent RNA polymerase.", BMC Bioinformatics. 2011 Jun 2;12(1):226. [MEDLINE]